Comparison of donidine and meth@dupa on blood pressure and side &ects in hypertensive patients

C lonidine hydrochloride (Catapres) represents a new type of antihypertensive agent which acts to reduce blood pressure by central inhibition of sympathetic vasomotor and cardioexcitatory stimuli.‘s2 We have previously demonstrated its antihypertensive effectiveness particularly when combined with a diuretic.3 The drug has been shown to have long-term effectiveness in the treatment of severe hypertension and sufficient potency to replace guanethidine. Sedation, constipation, and dry mouth are its chief side effects; they tend to decrease with the passage of time and are less objectionable than the fatigue and postural syncope frequently seen with guanethidine.4 Methods